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. 2022 May 3;17(5):e0267345. doi: 10.1371/journal.pone.0267345

Fig 6. BNST ChR2 stimulation of CRF-containing neurons fails to change cocaine pursuit.

Fig 6

Pairing ChR2 excitation of CRF neurons in BNST with one cocaine option failed to alter cocaine pursuit in the two-choice task for A) BNST ChR2 rats (n = 6); or B) BNST eYFP inactive control rats, (n = 6). C) BNST ChR2 stimulation had little no effect on total cocaine consumption in the two-choice task compared to eYFP controls plus Cocaine alone infusions). D) In progressive ratio (PR) tests, CRF-containing neuronal excitation failed to alter effort breakpoint of BNST ChR2 rats (n = 5; left panel), which remained similar also to the unchanging breakpoint of BNST eYFP control rats (n = 6). Right panel depicts timeframe of behavioral responses for cocaine during the 1hr PR sessions. Means and SEM reported.