Table 3. Associations between each Correlates of Risk (COR) signature and HIV acquisition, univariate and adjusted analyses.

CoR Scorea	Univariate regression estimates	Multivariate regression estimates
	ORc (95% CI)	aORb,c (95% CI)
RISK6d,e	1.06 (0.87, 1.31)	1.15 (0.92, 1.44)
Suliman4d	0.89 (0.72, 1.09)	0.89 (0.72, 1.11)
Sweeney3	1.34 (1.05, 1.70)	1.38 (1.07, 1.78)
Maertzdorf4	0.90 (0.73, 1.12)	0.89 (0.71, 1.13)
RESPONSE5	0.84 (0.67, 1.05)	0.78 (0.61, 0.98)

^aAll CoR scores in were modeled using conditional logistic regression accounting for matching variables (treatment arm, country).

^bOR and adjusted OR (aOR) are reported for 1 standard deviation change.

^cModels were fully fit with all variables that were associated with case control status: gender, risk score, and age.

^dVariables log transformed.

^ePrespecified as the primary transcriptomic signature of interest. The other four signatures were considered exploratory predictors.