Table 2. Comparative analysis of allele frequencies of the studied polymorphisms (MTHFR and DNMT3B) among the control, periodontitis, SLE and SLE + periodontitis groups.
| Gene SNP | MTHFR C677T(rs1801133) | DNMT3B C46359T (rs2424913) | ||
|---|---|---|---|---|
| Allelic frequency | C | T | C | T |
| Control 1 n=60 | 85 (70.80%) | 35 (29.20%) | 82 (68.30%) | 38 (31.70%) |
| Perio 2 n=51 | 69(67.60%) | 33(32.40%) | 48(47.06%) | 54(52.94%) |
| p value1.2 | 0.181 | 0.011 | ||
| SLE 3 n=47 | 70(74.50%) | 24(25.50%) | 37(39.36%) | 57(60.64%) |
| p value1.3 | 0.565 | <0.001 | ||
| Inactive SLE 4 n=20 | 28(70.00%) | 12(30.00%) | 13(32.50%) | 27(67.50%) |
| p value1.4 | 0.897 | 0.002 | ||
| Active SLE 5 n=27 | 42(77.78%) | 12(22.22%) | 24(44.44%) | 30(55.56%) |
| p value1.5 | 0.360 | 0.002 | ||
| SLE + Perio 6 n=38 | 51(67.10%) | 25(32.90%) | 41(53.95%) | 35(46.05%) |
| p value1.6 | 0.529 | 0.138 | ||
| Inactive SLE + Perio 7 n = 24 | 32(66.67%) | 16(33.33%) | 24(50.00%) | 24(50.00%) |
| p value1.7 | 0.810 | 0.020 | ||
| Active SLE + Perio 8 n= 14 | 19(67.86%) | 09(32.14%) | 17(60.71%) | 11(39.29%) |
| p value1.8 | 0.773 | 0.370 | ||
Chi-Square test and Chi-Square test with Yates’s correction. Significance level = 5%.