Table 3. Comparative analysis of genotype frequencies of the studied polymorphisms (MTHFR and DNMT3B) among the control, periodontitis, SLE and SLE + periodontitis groups.
| Gene SNP | MTHFR C677T (rs1801133) | DNMT3B C46359T (rs2424913) | ||||
|---|---|---|---|---|---|---|
| Genotype frequencies | CC | CT | TT | CC | CT | TT |
| Control 1 | 31 | 23 | 6 | 27 | 28 | 5 |
| n=60 | (51.70%) | (38.30%) | (10.00%) | (45.00%) | (46.70%) | (8.30%) |
| Perio 2 | 21 | 27 | 3 | 11 | 26 | 14 |
| n=51 | (41.20%) | (52.90%) | (5.90%) | (21.60%) | (51.00%) | (27.50%) |
| p-value 1 , 2 | 0.275 | 0.005 | ||||
| SLE 3 | 27 | 16 | 4 | 8 | 21 | 18 |
| n=47 | (57.40%) | (34.00%) | (8.50%) | (17.00%) | (44.70%) | (38.30%) |
| p-value 1 , 3 | 0.842 | <0.001 | ||||
| Inactive SLE 4 | 10 | 8 | 2 | 1 | 11 | 8 |
| n=20 | (50.00%) | (40.00%) | (10.00%) | (5.00%) | (55.00%) | (40.00%) |
| p-value 1 , 4 | 0.991 | <0.001 | ||||
| Active SLE 5 | 17 | 8 | 2 | 7 | 10 | 10 |
| n=27 | (63.00%) | (29.60%) | (7.40%) | (26.00%) | (37.00%) | (37.00%) |
| p-value 1 , 5 | 0.618 | 0.003 | ||||
| SLE + Perio 6 | 19 | 13 | 6 | 11 | 19 | 8 |
| n=38 | (50.00%) | (34.20%) | (15.80%) | (28.90%) | (50.00%) | (21.10%) |
| p-value 1 , 6 | 0.735 | 0.105 | ||||
| Inactive SLE +Perio7 | 11 | 10 | 3 | 7 | 10 | 7 |
| n=24 | (45.80%) | (41.70%) | (12.50%) | (29.20%) | (41.70%) | (29.20%) |
| p-value 1 , 7 | 0.876 | 0.042 | ||||
| Active SLE +Perio8 | 8 | 3 | 3 | 4 | 9 | 1 |
| n=14 | (57.20%) | (21.40%) | (21.40%) | (28.60%) | (64.30%) | (7.10%) |
| p-value 1 , 8 | 0.378 | 0.620 | ||||
Chi-Square test and Chi-Square test with Yates’s correction. Significance level = 5%.