TABLE 5.
Treatment regimens of patients with codon 69 mutations
| Mutation | Patients with defined history/total no. of patientsa | No. of patients with mutation after regimen | Treatment regimen |
|---|---|---|---|
| T69D | 39/86 | 5 | AZT monotherapy |
| 5 | AZT then AZT + ddI | ||
| 5 | AZT + 3TC | ||
| 4 | AZT + ddI | ||
| 3 | AZT, then AZT + ddC | ||
| 2 | AZT + ddI, then AZT + 3TC | ||
| 62 | Multipleb | ||
| T69N | 36/57 | 11 | AZT monotherapy |
| 10 | AZT + 3TC | ||
| 4 | AZT, then ddI | ||
| 4 | AZT, then AZT + ddI | ||
| 3 | 3TC monotherapy | ||
| 25 | Multiple | ||
| T69S | 16/28 | 3 | AZT + 3TC |
| 3 | ddI, then AZT + ddI | ||
| 2 | AZT monotherapy | ||
| 2 | AZT, then AZT + ddC | ||
| 18 | Multiple | ||
| T69A | 10/12 | 12 | Multiple |
| T69I | 4/5 | 2 | AZT + ddI |
| 3 | Multiple | ||
| T69E | 2/3 | 3 | Multiple |
| T69G | 2/2 | 2 | Multiple |
| T69K | 1/1 | 1 | Multiple |
a
Patients with defined history are those for which the exact sequence and combinations of drugs are known; others are known to have NRTI experience, but the precise sequence and/or combinations are not known.
b
Multiple regimens include single occurrences of patients that received three or less drugs, patients that received more than three drugs in more than three regimens, and patients with confirmed but undefined NRTI experience.