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. 2022 Apr 29;16:1273–1287. doi: 10.2147/DDDT.S362754

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© 2022 Yao et al.

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ISL alleviates oxidative stress after AMI by regulating Nrf2 activity. (A) DHE staining was used to detect ROS levels in the hearts of mice in each group, n = 5 in each group. Scale bar, 100 μm. (B) ImageJ software was used to analyze the average fluorescence intensity of ROS staining. (C) Lipid peroxidation (MDA) assay kit was used to measure MDA production in myocardial tissue. n = 5–7 in each group. (D) SOD activity in myocardial tissue was measured with a SOD assay kit. n = 5–7 in each group. (E) Detection of GSH-Px content in myocardial tissue with a GSH-Px kit. n = 5–7 in each group. Data are presented as mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001.