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. 2022 Apr 26;2022:1758113. doi: 10.1155/2022/1758113

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Copyright © 2022 Chang Zhu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Differential metabolites for CRC urine sample compared to control. (a) Volcano plot for differential metabolites identified by OPLS-DA in CRC patients vs controls (VIP>1, |correlation coefficient| >0.3). (b) Volcano plot for differential metabolites identified by univariate statistical analysis in CRC patients vs controls (p <0.05, significantly increased metabolites in CRC (FC>1, red dots) and significantly decreased metabolites in CRC (FC<1, blue dots). (c) Heatmap of differential biomarkers of CRC patients vs controls (Z-score scale to -2~2). (d) Box plot of representative differential metabolites with significantly different concentration in CRC sample vs control (p <0.05).