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. 2019 Jun 7;9(30):17457–17472. doi: 10.1039/c9ra01838g

Pharmacodynamics of prototype compounds in THM and its metabolites in the gut.

Prototype compounds in THM Metabolites in gut The efficacy of metabolites superior to prototypes
Ginsenosides/ginsenoside Re Compound K/ginsenoside Rh1 Hepato-protective, anti-cancer, anti-wrinkling, and anti-aging properties/estrogenic effect
Glycyrrhizin Glycyrrhetic acid Anti-hepatotoxicity
Lancemaside A Echinocystic acid Anti-inflammatory, anti-tumor and anti-Alzheimer's disease
Baicalin Baicalein, orohylin A Anti-histamine-induced pruritus response
Poncirin Ponciretin Anti-inflammatory
Sennosides Rheinanthrone Diarrheal and laxative effect
Barbaloin Aloe-rheinanthrone Diarrheal effect
Rhapontin Rhapontigenin Antithrombotic and anti-allergic effects
Geniposide Genipin Cholagogue effects