Significantly different proteins produced in the liver after the intervention of Scrophulariaceae in normal rats (difference multiple >1.2 or <0.8)^a.

No.	Accession	Gene name	Description	Average ratio Q/K	Trends Q/K	P value
L1	Q6MG32	RT1-CE12	RT1 class I, CE12	0.4685	Down**	0.0002
L2	Q63042	Gfer	FAD-linked sulfhydryl oxidase ALR	0.5479	Down**	0.0022
L3	A0A0G2JSK1	Serpina3c	Protein Serpina3c	0.5502	Down**	0.0001
L4	P35286	Rab13	Ras-related protein Rab-13	0.6139	Down*	0.0458
L5	M0R9Q1	Rbm14	Protein Rbm14	0.6297	Down**	0.0005
L6	Q4VBH1	Ighg	Ighg protein	0.6415	Down**	0.0004
L7	A0A023IKI3	Psmb8	Proteasome subunit beta type	0.6454	Down**	0.0047
L8	A0A0G2JX10	Anks3	Ankyrin repeat and SAM domain-containing protein 3	0.6764	Down**	0.0022
L9	P70473	Amacr	Alpha-methylacyl-CoA racemase	0.6981	Down**	0.0003
L10	M0RAJ5	Prr14l	Protein Prr14l	0.7129	Down**	0.0069
L11	Q6P756	Necap2	Adaptin ear-binding coat-associated protein 2	0.7407	Down*	0.0151
L12	Q80W92	Vac14	Protein VAC14 homolog	0.7429	Down*	0.0338
L13	A0A097PE04	COX2	Cytochrome c oxidase subunit 2	0.7470	Down**	0.0005
L14	Q5RK24	Pmvk	Phosphomevalonate kinase	0.7552	Down**	0.0019
L15	Q99MS0	Sec14l2	SEC14-like protein 2	0.7571	Down**	0.0009
L16	E9PU17	Abca17	ATP-binding cassette sub-family A member 17	0.7599	Down*	0.0271
L17	F1LM99	Phf12	PHD finger protein 12	0.7733	Down**	0.0045
L18	A0A0G2JVQ0	Rnf111	Protein Rnf111	0.7744	Down*	0.0444
L19	D3ZTW7	Atpaf2	ATP synthase mitochondrial F1 complex assembly factor 2 (predicted), isoform CRA_c	0.7886	Down**	0.0012
L20	P43424	Galt	Galactose-1-phosphate uridylyltransferase	0.7907	Down**	0.0076
L21	A0A0G2JV37	LOC100910040	Carboxylic ester hydrolase	0.7914	Down*	0.0305
L22	P49889	Ste	Estrogen sulfotransferase, isoform 3	0.7941	Down**	0.0050
L23	Q6AYW2	Pah	Phenylalanine hydroxylase	0.7994	Down**	0.0088
L24	P55006	Rdh7	Retinol dehydrogenase 7	0.8006	Down**	0.0001
L25	P0C5E9	Crygs	Beta-crystallin S	0.8026	Down**	0.0075
L26	A0A0G2KA12	Kif1b	Kinesin-like protein KIF1B	0.8111	Down*	0.0244
L27	F1LRB8	Mat2a	S-Adenosylmethionine synthase	0.8113	Down**	0.0057
L28	B2GV29	Trmt13	Ccdc76 protein	0.8139	Down**	0.0016
L29	Q4QR81	Rbms2	Protein Rbms2	0.8203	Down*	0.0224
L30	D4AAP6	Mn1	Protein Mn1	0.8215	Down**	0.0016
L31	D4AB73	Sprtn	Putative uncharacterized protein RGD1559496_predicted	0.8298	Down*	0.0177
L32	Q5XHZ8	Cog3	Component of oligomeric golgi complex 3	1.2021	Up**	0.0011
L33	P00502	Gsta1	Glutathione S-transferase alpha-1	1.2046	Up**	0.0000
L34	P19488	Ugt2b37	UDP-glucuronosyltransferase 2B37	1.2057	Up**	0.0045
L35	Q6AXQ0	Sae1	SUMO-activating enzyme subunit 1	1.2057	Up*	0.0347
L36	F1LNM4	LOC103689965	Complement C4 (fragment)	1.2075	Up**	0.0039
L37	F1LU27	Focad	Protein Focad	1.2138	Up*	0.0489
L38	Q32PY9	Idnk	Probable gluconokinase	1.2167	Up**	0.0068
L39	G3V647	Pdxk	Pyridoxal kinase	1.2222	Up**	0.0010
L40	P05545	Serpina3k	Serine protease inhibitor A3K	1.2300	Up**	0.0100
L41	G3V9N9	Man1a1	Alpha-1,2-mannosidase	1.2303	Up**	0.0040
L42	Q566C7	Nudt3	Diphosphoinositol polyphosphate phosphohydrolase 1	1.2349	Up**	0.0001
L43	F1LN59	Eif4g2	Protein Eif4g2	1.2408	Up**	0.0084
L44	D4A284	Nell1	NEL-like 1 (chicken), isoform CRA_a	1.2417	Up*	0.0180
L45	D3ZNJ5	Inmt	Protein Inmt	1.2494	Up**	0.0027
L46	A0A0G2JU41	Dyrk4	Protein Dyrk4	1.2503	Up**	0.0015
L47	D4ADS4	Mgst3	Protein Mgst3	1.2523	Up**	0.0007
L48	A0A0G2JSR8	Cyp17a1	Cytochrome P450, family 17, subfamily a, polypeptide 1	1.2576	Up**	0.0077
L49	A2VCW9	Aass	Alpha-aminoadipic semialdehyde synthase, mitochondrial	1.2637	Up**	0.0000
L50	F1M7N8	Ugt2b37	UDP-glucuronosyltransferase	1.2647	Up**	0.0010
L51	P38659	Pdia4	Protein disulfide-isomerase A4	1.2670	Up**	0.0018
L52	Q6AXR4	Hexb	Beta-hexosaminidase subunit beta	1.2712	Up**	0.0021
L53	D4A3E8	Mrps27	Mitochondrial ribosomal protein S27 (predicted), isoform CRA_b	1.2733	Up*	0.0453
L54	D3ZES7	Plxna4	Protein Plxna4	1.2853	Up**	0.0001
L55	P05183	Cyp3a2	Cytochrome P450 3A2	1.3085	Up**	0.0002
L56	Q5XIG0	Nudt9	ADP-ribose pyrophosphatase, mitochondrial	1.3121	Up**	0.0001
L57	Q920L7	Elovl5	Elongation of very long chain fatty acids protein 5	1.3239	Up**	0.0021
L58	P08290	Asgr2	Asialoglycoprotein receptor 2	1.3334	Up*	0.0127
L59	A0A023IM45	Psmb8	Proteasome subunit beta type	1.3358	Up**	0.0020
L60	Q62730	Hsd17b2	Estradiol 17-beta-dehydrogenase 2	1.3607	Up**	0.0000
L61	Q31256	N/A	MHC class I RT1.Au heavy chain	1.3778	Up**	0.0003
L62	A0A0A1G491	ND2	NADH-ubiquinone oxidoreductase chain 2	1.3851	Up*	0.0195
L63	P20814	Cyp2c13	Cytochrome P450 2C13, male-specific	1.4111	Up**	0.0000
L64	F1LMF4	Fat3	Protocadherin fat 3	1.4253	Up**	0.0060
L65	Q4V797	RGD1309362	Interferon-gamma-inducible GTPase Ifgga1 protein	1.4272	Up**	0.0000
L66	P50169	Rdh3	Retinol dehydrogenase 3	1.4563	Up**	0.0000
L67	A0A0G2K222	N/A	Uncharacterized protein	1.5162	Up	0.0272
L68	Q5UAJ6	COX2	Cytochrome c oxidase subunit 2	1.5316	Up**	0.0001
L69	M0RC39	Olr796	Olfactory receptor	1.5880	Up*	0.0484
L70	D3ZMQ0	Mga	Protein Mga	1.6374	Up*	0.0312
L71	Q6T5E9	Ugt1a6	UDP-glucuronosyltransferase	1.7279	Up**	0.0003
L72	A1XF83	Ugt2b	UDP-glucuronosyltransferase	1.8256	Up**	0.0001
L73	D3ZXC8	Ebpl	Emopamil binding protein-like (predicted), isoform CRA_a	1.8324	Up**	0.0018
L74	F1LM22	Ugt2b	UDP-glucuronosyltransferase	1.8894	Up**	0.0000
L75	Q63002	Igf2r	Mannose 6-phosphate/insulin-like growth factor II receptor	2.1130	Up**	0.0080
L76	Q5BK88	Amacr	Alpha-methylacyl-CoA racemase	2.5845	Up**	0.0001

^aCompared with control group, *p < 0.05,**p < 0.01. L represents liver. K represents control group, Q represents R. Scrophulariae group.