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Effect of 40 mg of ACV/kg on the replication of HSV-1 in rat brain. The efficacy of 40 mg of ACV/kg administered during infusion with 6 μg of Cereport/ml was determined 7 days after infection in various portions of the rat brain. HSV-1 titers are expressed as the mean log10 PFU/gram of tissue ± the standard deviation. Means reflect values obtained from three animals that survived out of five in each group. A value of 1 log10 PFU/g of tissue is the lowest detectable limit.
