TABLE 3.
Uptake of [14C] ACV in uninfected and HSV-1-infected rats infused with Cereport
| Organ or fluid (min) | Uptakea of [14C]ACV in rats
|
|||
|---|---|---|---|---|
| Uninfected
|
HSV-1 infected
|
|||
| Saline | Cereport | Saline | Cereport | |
| Brain | 1.4 ± 0.2 | 4.1 ± 0.7 | 1.7 ± 0.3 | 3.5 ± 0.7 |
| Plasma (10) | 43.0 ± 4.6 | 107.7 ± 23.1 | 103.7 ± 24.5 | 73.6 ± 17.3 |
| Plasma (20) | 20.7 ± 3.5 | 84.1 ± 19.0 | 74.2 ± 14.3 | 29.5 ± 5.0 |
| Blood cells (10) | 6.8 ± 3.4 | 8.4 ± 5.4 | 6.3 ± 1.3 | 7.1 ± 4.1 |
| Blood cells (20) | 3.3 ± 1.2 | 6.2 ± 3.7 | 5.7 ± 2.3 | 2.9 ± 1.4 |
| CSF | 1.2 ± 0.2 | 4.9 ± 3.8 | 7.9 ± 3.0 | 4.6 ± 2.9 |
| Plasma/CSF ratio (20) | 17.3 ± 4.2 | 22.5 ± 10.2 | 10.0 ± 2.8 | 9.4 ± 7.3 |
a
Values are micromolar, except for those of brain, which are expressed in nanomoles per gram.