Table 1.

Sporulation genes of interest within C. difficile.

Gene name	Locus taga	Known or predicted function	References
spo0A	CD1214	Master transcriptional regulator of sporulation	[2,3]
sigH	CD0057	Transition/stationary-phase sigma factor	[14]
rstA	CD3668	Multifunctional regulator; promotes sporulation	[14, 15, 16**]
spo0E	CD3271	Putative Spo0A phosphatase; sporulation inhibition
PtpA	CD1492	Sporulation inhibition	[11*]
PtpB	CD2492	Sporulation inhibition
PtpC	CD1579	Sporulation inhibition
sigB	CD0011	Alternative sigma factor; stress responses; sporulation inhibition	[29–31]
ccpA	CD1064	Carbon catabolite control, transcriptional regulator; cofactor: fructose-1,6-bisphosphate; sporulation inhibition	[34*]
codY	CD1275	Transcriptional regulator; cofactors: GTP and BCAA; sporulation inhibition	[38**–40*]
agrB1D1	CD27491–50	quorum-sensing related sporulation inhibition	[48**]
oppA-F	CD0853–57	Putative peptide permease; sporulation inhibition	[49]
appA-F	CD2670–74	Putative peptide permease; sporulation inhibition	[49]
sin	CD2214–15	sporulation	[53*,54]
csiA	CD2589	Conditional repression of sporulation	[57]
kipI-kipA	CD1386–87	Putative inhibitor of histidine kinase
spo0J-soj-spo0J2	CD3671–73	Putative inhibitor of sporulation gene transcription

^aLocus tag number based on C. difficile 630 reference genome (GenBank: AM180355)