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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Gynecol Oncol. 2022 Mar 12;165(2):239–247. doi: 10.1016/j.ygyno.2022.02.022

Figure 2: Volcano plot of genes differentially expressed in normal and ovarian tumor tissue pre vs post HIPEC with platinum exposure.

Figure 2:

Differentially expressed genes after HIPEC with platinum exposure in normal (left) and tumor (right) tissues, plotted as Log2 fold-change in the x-axis and −Log10 q-value on the y-axis. Expression of genes colored as red (up-regulation) and blue (down-regulation) dots has significantly changed after HIPEC with platinum exposure with a p-value <0.05 and a Log2 fold-change >1.5. Genes highlighted with a yellow box represent the four most significantly upregulated genes related to immune response after HIPEC in normal tissue, whereas those with a light blue box represent the four most significantly upregulated genes after HIPEC in tumor tissue, which are heat shock proteins.