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. 2022 May 3;12:181. doi: 10.1038/s41398-022-01952-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The top panel (1) depicts the experimental protocol. Vertical arrows represent intraperitoneal MDMA (5 mg/kg) or saline injection. Rats were exposed for 10 min to predator-scent stress (PSS) or to sham-PSS on day 0. On day 7, rats received MDMA (sham-PSS + MDMA: n = 10; PSS-exposed + MDMA: n = 10) or saline (sham-PSS + saline: n = 11; PSS-exposed + saline: n = 10) and 30 min later were exposed to a trauma-cue for 10 min. On Day 16, rats were sacrificed and their brains collected for morphological staining. A Sholl analysis for intersections per 15-μm radial unit distance of dentate gyrus granule cells from the suprapyramidal blade. * Sham-PSS + MDMA ≠ PSS + MDMA, p < 0.05. ^#PSS + saline ≠ PSS + MDMA, p < 0.05. ^@PSS + saline ≠ PSS + MDMA, sham-PSS + saline, p < 0.05. B Sholl analysis for intersections per 15-μm radial unit distance of pyramidal neurons of the basolateral amygdala. ^{^}PSS + saline ≠ sham-PSS + saline & sham-PSS + MDMA, p < 0.03. * PSS + saline ≠ sham-PSS + saline & sham-PSS + MDMA & PSS + MDMA, p < 0.03. ^@PSS + saline ≠ sham-PSS + saline & PSS + MDMA, p < 0.05. ^#PSS + saline ≠ sham-PSS + saline, p < 0.04. C Computer-generated reconstructions of dendritic trees from granule cells and pyramidal cells in all groups. (2) depicts the experimental protocol. Vertical arrows represent intraperitoneal MDMA (5 mg/kg) or saline injection. Corticosterone concentrations (pg/ml) measured at 120- and 240 min post MDMA treatment in sham-PSS treated with saline (Sham-PSS + saline, n = 10) or MDMA (Sham-PSS + MDMA, n = 10), PSS-exposed animals treated with saline (PSS + saline, n = 10), or PSS-exposed treated with MDMA (PSS-MDMA, n = 9). D corticosterone concentrations** (pg/ml) were measured. The experiments described below were performed with two different cohorts of animals; 20 rats were run in one experimental design, and 19 rats in another experimental design. Bars represent group means ± SEM.