Fig. 4.

Inferring inter-cellular communication by single-cell sequencing. Inter-cellular contact or transfer of informative material is essential for coordinating the antitumor immune response and the malignant phenotype of tumor cells. Dissecting inter-cellular communication with single-cell sequencing analysis is instructive in understanding active signaling pathways between different cell types, which could eventually be applied to construct a communication network in the tumor immune microenvironment