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. 2022 May 3;12:7154. doi: 10.1038/s41598-022-11189-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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G protein signaling of novel mixed MOP/NOP agonists measured by GTPƔS assay. Concentration–response curves obtained for prototypical selective agonist DAMGO (A) and N/OFQ (G), novel mixed MOP/NOP agonists cebranopadol (B, H), AT-034 (C, I), AT-324 (D, J), AT-201 (E, K), AT-121 (F, L) at MOP and NOP, respectively, in stably expressing CHO cells. Each data point (mean ± SEM) was calculated from at least three independent experiments conducted in triplicates.