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. 2022 May 3;5:409. doi: 10.1038/s42003-022-03325-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Comparison of neutralisation titres between SARS-CoV-2 and RaTG13 using the WHO International Reference Panel for anti-SARS-CoV-2 immunoglobulin. Three of the four sera showed increased neutralisation titres against RaTG13. b Comparison of neutralisation titres between SARS-CoV-2 (n = 25), RaTG13 (n = 25, p = <0.0001), B.1.351 (Beta) (n = 25, p = <0.0001) variant of concern, SARS-CoV-1 (n = 25, p = <0.0001) and WIV16 (n = 25, p = <0.0001) using convalescent sera derived from patients and healthcare workers. c Comparison of neutralisation titres between SARS-CoV-2 and RaTG13 against sera from single-dose vaccinated healthcare workers (n = 21, p = 0.0016). d Differences in neutralisation titre from single dose vaccinated healthcare workers split by ‘no prior infection’ (n = 11, p = 0.001) or ‘prior infection’ (n = 10, p = 0.084) with SARS-CoV-2. Full circles denote healthcare workers vaccinated with BNT162b2 (n = 12), whereas open circles denote vaccination with AZD1222 (n = 9). Numbers in brackets denote fold changes relative to SARS-CoV-2. Wilcoxon matched pairs signed rank tests were used in panels (b), (c) and (d). Dotted lines in graphs denote the assay’s lower limit of detection. IC50 was calculated by fitting a non-linear regression curve using Graphpad Prism 8 software. All n values constitute of biologically independent samples.