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. 2022 May 3;13(5):427. doi: 10.1038/s41419-022-04857-y

Fig. 4. POU6F1 represses the growth and aggressiveness of LUAD cells in vivo.

Fig. 4

A Representative images of xenografts formed by subcutaneous injection of A549 cells stably transfected with empty vector (mock) or POU6F1 into the dorsal flanks of nude mice (n = 5 for each group). B Tumor weight at the endpoints (B left panel) and in vivo growth curve (B right panel) of xenografts formed by subcutaneous injection of A549 cells stably transfected with mock or POU6F1 into the dorsal flanks of nude mice (n = 5 for each group). C Representative images (left panel) and quantification (right panel) of immunohistochemical staining revealing the expression of Ki-67 and CD31 within xenografts formed by subcutaneous injection of A549 cells stably transfected with mock or POU6F1 into dorsal flanks of nude mice. Scale bar: 100 μm. D–F Representative images (D), HE staining (E), metastatic counts of lungs (F left panel), and Kaplan–Meier curves (F right panel) of nude mice treated with tail vein injection of A549 cells stably transfected with mock or POU6F1 (n = 5 for each group). Scale bar: 100 μm. *P < 0.05, **P < 0.01.