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. 2022 May 3;12:7199. doi: 10.1038/s41598-022-10453-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Postnatal development of the IA-task-induced synaptic plasticity. (A) Representative traces of mEPSCs and mIPSCs sequentially recorded in the same CA1 pyramidal neuron in the presence of tetrodotoxin (0.5 µM). Vertical bar = 20 pA; horizontal bar = 50 ms. (B) Two-dimensional plots of the mean mEPSC and mIPSC amplitudes in an individual neuron (upper panel), and results of the kernel density analysis visualizing the distribution of the appearance probability at any point (lower panel). (C) Two-dimensional plots of the mean mEPSC and mIPSC frequencies in an individual neuron (upper panel), and visualization of the kernel density distribution (lower panel). (D) Postnatal changes in the mean mEPSC (left) and mIPSC (right) amplitudes in untrained (gray) and trained (black) rats. The IA task increased mEPSC amplitude at 3 and 4 weeks and increased mIPSC amplitude at 4–8 weeks. (E) Postnatal changes in the mean mEPSC (left) and mIPSC (right) frequencies in untrained (gray) and trained (black) rats. The training increased the frequencies of both mEPSCs and mIPSCs at 3 and 4 weeks, and decreased these frequencies at 2 weeks. The numbers under the graphs indicate the number of neurons. The error bars indicate ± SEM. *P < 0.05, **P < 0.01 vs. untrained.