Table 1.
Gene ontology (GO) term analysis of Titan-specific RDD (regions of distinct genetic differentiation) genes shows enrichment of altered genes in different biological processes connected to growth and metabolic regulation.
| GO ID | Term name | Enrichment ratio | FDR | NCBI gene ID | Gene symbol |
|---|---|---|---|---|---|
| GO:0031424 | Keratinization | 21.7 | 0.020 | 20754; 20762; 20763; 20765; 20766 | Sprr2h; Sprr2i; Sprr2k; Sprr1b; Sprr3 |
| GO:0044262 | Cellular carbohydrate metabolic process | 5.3 | 0.050 | 11677; 12015; 14042; 14534; 15531; 20848; 50798; 50873; 58246; 66646 | Rpe; Gne; Slc35b4; Akr1b3; Kat2a; Stat3; Ext1; Prkn; Ndst1; Bad |
| GO:0060343 | Trabecula formation | 22.5 | 0.050 | 14225; 15214; 21687; 170826 | Fkbp1a; Tek; Hey2; Ppargc1b |
| GO:0060416 | Response to growth hormone | 21.7 | 0.050 | 20848; 20850; 20851; 227231 | Cps1; Stat5b; Stat5a; Stat3 |
| GO:0009913 | Epidermal cell differentiation | 6.1 | 0.065 | 15214; 20754; 20762; 20763; 20765; 20766; 22283; 67694 | Ush2a; Sprr2h; Sprr2i; Sprr2k; Sprr1b; Sprr3; Ift74; Hey2 |
| GO:0010918 | Positive regulation of mitochondrial membrane potential | 35.1 | 0.068 | 12015; 50873; 269523 | Vcp; Prkn; Bad |
| GO:0072044 | Collecting duct development | 35.1 | 0.068 | 11677; 71228; 240025 | Akr1b3; Dlg5; Dact2 |
| GO:0060396 | Growth hormone receptor signaling pathway | 32.6 | 0.074 | 20848; 20850; 20851 | Stat5b; Stat5a; Stat3 |
| GO:0060347 | Heart trabecula formation | 30.4 | 0.074 | 14225; 15214; 21687 | Fkbp1a; Tek; Hey2 |
| GO:0045579 | Positive regulation of B cell differentiation | 30.4 | 0.074 | 12015; 20850; 20851 | Stat5b; Stat5a; Bad |
| GO:0046629 | Gamma-delta T cell activation | 28.5 | 0.075 | 20850; 20851; 270152 | Jaml; Stat5b; Stat5a |
| GO:0071378 | Cellular response to growth hormone stimulus | 28.5 | 0.075 | 20848; 20850; 20851 | Stat5b; Stat5a; Stat3 |
| GO:0050891 | Multicellular organismal water homeostasis | 14.5 | 0.075 | 11677; 20276; 22393; 229574 | Flg2; Wfs1; Akr1b3; Scnn1a |
| GO:0035966 | Response to topologically incorrect protein | 7.4 | 0.075 | 22393; 50873; 56323; 69310; 69601; 269523 | Dab2ip; Dnajb5; Vcp; Wfs1; Pacrg; Prkn |
| GO:0072528 | Pyrimidine-containing compound biosynthetic process | 14.1 | 0.075 | 29807; 68262; 69692; 227231 | Cps1; Tpk1; Hddc2; Agpat4 |
| GO:0030216 | Keratinocyte differentiation | 7 | 0.086 | 20754; 20762; 20763; 20765; 20766; 67694 | Sprr2h; Sprr2i; Sprr2k; Sprr1b; Sprr3; Ift74 |
| GO:0030104 | Water homeostasis | 13.2 | 0.086 | 11677; 20276; 22393; 229574 | Flg2; Wfs1; Akr1b3; Scnn1a |
| GO:0045838 | Positive regulation of membrane potential | 24 | 0.086 | 12015; 50873; 269523 | Vcp; Prkn; Bad |
| GO:0030856 | Regulation of epithelial cell differentiation | 6.7 | 0.093 | 12015; 15214; 20850; 20851; 21937; 74123 | Tnfrsf1a; Hey2; Stat5b; Stat5a; Foxp4; Bad |
| GO:0061383 | Trabecula morphogenesis | 12.4 | 0.094 | 14225; 15214; 21687; 170826 | Fkbp1a; Tek; Hey2; Ppargc1b |
| GO:0043588 | Skin development | 4.7 | 0.095 | 20754; 20762; 20763; 20765; 20766; 67694; 229574; 240025 | Sprr2h; Sprr2i; Sprr2k; Sprr1b; Sprr3; Flg2; Ift74; Dact2 |
p value adjustment with Benjamin–Hochberg procedure for false discovery rate (FDR).