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. 2022 May 3;12:7140. doi: 10.1038/s41598-022-10777-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proportion of Preferred Terms (MedDRA) with positive IC025 related to each JAK inhibitor according to the 27 different System Organ Classes. “Pregancy, puerperium and perinatal conditions” is not represented here because of no positive IC025 observed for any of the three drugs. Yellow curve represents tofacitinib, orange baricitinib and blue ruxolitinib. MedDRA: Medical Dictionary for Regulatory Activities; IC₀₂₅: lower limit of the 95% credibility interval of the information component. A positive IC₀₂₅ is the statistical threshold used in VigiBase.