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. 2022 May 3;13:2400. doi: 10.1038/s41467-022-30003-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Comparison of HRD signature scores, estimated by SigMA for TCGA (n = 495), PCBM primary (n = 63), CRPC500 non-brain metastatic (n = 411), and PCBM metastatic (n = 105) samples (Wilcoxon test, two sided). Horizontal lines in boxplots show median, hinges show interquartile range, whiskers show 1.5 x interquartile range, points beyond 1.5 x IQR past hinge are shown. b Summary of mutations and copy number alterations affecting HR genes included in the PROfound clinical trial. Alterations (coding and copy number) are colored according to the legend. Ploidy annotation from FACETS and samples passing the HRD Signature ‘strict’ cutoff from SigMA are indicated. Source data are provided as a Source Data file.