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. 2022 Apr 4;12(7):3251–3272. doi: 10.7150/thno.70623

Figure 8.

Figure 8

In vivo biodistribution and radiological evaluation of 4-OI@Zn-NH-pyr on acute arthritis in TMJ. (A) Schematic diagram of the in vivo evaluation. (B) Illustration of preparing emulsion of CFA and type II collagen, and intra-articular injection in rat TMJ. (C) IVIS images of the biodistribution of Cy7@Zn-NH-pyr and its excretion (n = 3 independent animals). (D) Body weight of rats administrated with various treatment groups (mean ± SD, n = 3 independent animals). (E) Representative images of micro-CT scanning of rat TMJ on day 7 and 14 after administration of various treatment groups (n = 3 independent animals). (F) Quantitative analysis of micro-CT scanning of rat TMJ on day 7 and 14 after administration with various treatment groups (mean ± SD, one-way ANOVA with Tukey's multiple comparison test, n = 3 independent animals). *P < 0.05; **P < 0.01.