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. 2022 Apr 4;12(7):3251–3272. doi: 10.7150/thno.70623

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Histological analysis of the therapeutic effect of 4-OI@Zn-NH-pyr on acute arthritis in TMJ. (A) Representative images of H&E, S&F, TRAP, and immunostaining of iNOS and Nrf2 on day 7 after administration of various treatment groups (10 days after immunization) (n = 3 independent animals). (B) Representative images of H&E, S&F, TRAP, and immunostaining of iNOS and Nrf2 on day 14 after administration of various treatment groups (17 days after immunization) (n = 3 independent animals). (C) Quantitative analysis of the synovitis score. (D) Quantitative analysis of the OARSI score. (E) Quantitative analysis of the number of TRAP-positive OCs. (F) Quantitative analysis of the percentage of iNOS-positive cells. (G) Quantitative analysis of the percentage of Nrf2-positive cells. Data are presented as the mean ±SD (n = 3 independent animals). Statistical significance was determined by one-way ANOVA with Tukey's multiple comparison test. Black arrow, TRAP-positive OCs; SM, synovial macrophages; AC, articular cavity. *P < 0.05; **P < 0.01.