Figure 12.

Schematic illustration of AGA therapy through a ceria nanozyme (CeNZ)-integrated MNs (Ce-MNs) patch. (A) Fabrication of Ce-MNs. After modification by DSPE-mPEG₂₀₀₀, the CeNZs are encapsulated in the HA-based MNs. The backing layer of the patch is made of PVP-K90. (B) Five minutes after the Ce-MNs are applied to the skin, the PVP patch backing could be detached from the MNs. CeNZs can be delivered into the dermis and epidermis directly to scavenge excessive ROS. The mechanical stimulation induced by the administration of Ce-MNs can remodel the microvasculature in the perifollicular microenvironment. (C) Subsequently, the hostile oxidative microenvironment around the hair follicles is reshaped and angiogenesis is promoted by Ce-MNs, resulting in a fast onset of telogen-to-anagen transition of hair follicles. Adapted with permission from reference ¹⁶¹. Copyright 2021 American Chemical Society.