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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Pediatr Res. 2021 Nov 4;92(2):580–591. doi: 10.1038/s41390-021-01785-z

Figure 4.

Figure 4.

Volcano plots of associations between metabolic functional pathways and BASC-2 scores. Estimates, standard errors, p-values, and FDR q-values derive from MaAsLin2 models where the pathway relative abundance is modeled as the outcome and the given BASC-2 is treated as the exposure. All models adjust for the main effect child sex, gestational age, maternal education, parity, delivery mode, maternal and paternal age at delivery, maternal smoking during pregnancy, early life exclusive breastfeeding, duration of any breastfeeding, and child age at follow up. ASPASN.PWY: superpathway of L-aspartate and L-asparagine biosynthesis, PYRIDNUCSAL.PWY: NAD salvage pathway I (PNC VI cycle), PWY.5415: catechol degradation I (meta-cleavage pathway), DENOVOPURINE2.PWY: superpathway of purine nucleotides de novo biosynthesis II, PWY.4981: L-proline biosynthesis II (from arginine), PWY.7399: methylphosphonate degradation II, PWY4FS.7: phosphatidylglycerol biosynthesis I (plastidic), PWY4FS.8: phosphatidylglycerol biosynthesis I (non-plastidic), PWY.7111: pyruvate fermentation to isobutanol (engineered), PWY.5910: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate), PWY.7580: phycoerythrobilin biosynthesis II, PWY.7187: pyrimidine deoxyribonucleotides de novo biosynthesis II, 7ALPHADEHYDROX.PWY: bile acid 7α-dehydroxylation, PWY.922: mevalonate pathway I (eukaryotes and bacteria).