Table 5.

Total serum levels of tryptophan, kynurenine, and 3-hydroxykynurenine, kynurenine to tryptophan ratio, aldosterone, renin and metanephrines in patients on the lower dose hydrocortisone (0.2-0.3 mg/kg/day) with or without a history of an adrenal crisis.

	Adrenal crisis -	Adrenal crisis +	P value
Tryptophan-kynurenine metabolism	(n=39)	(n=7)
Tryptophan (µmol/L)	71.07 [58.75; 83.49]	74.82 [58.53; 80.95]	0.72
Kynurenine (µmol/L)	2.23 [1.82; 2.38]	2.64 [2.43; 3.28]	0.03
3-Hydroxykynurenine (µmol/L)	0.04 [0.03; 0.05]	0.05 [0.04; 0.08]	0.06
Kynurenine/tryptophan ratio	0.03 [0.03; 0.04]	0.04 [0.03; 0.05]	0.06
Renin-angiotensin-aldosterone system	(n=38)	(n=6)
Aldosterone (pmol/L)	135.00 [67.00; 263.00]	200.50 [159.25; 330.25]	0.16
Renin (pg/mL)	10.75 [6.56; 17.73]	16.40 [11.95; 44.60]	0.09
Aldosterone/renin ratio (pmol/ng)	12.20 [3.24; 21.25]	12.26 [7.24; 17.43]	0.98
Use of RAAS interfering medication (yes/no)	13/30	4/5	0.45
Potassium (mmol/L)	3.90 [3.65; 4.00]	3.90 [3.75; 4.15]	0.44
Adrenal medulla activity	(n=39)	(n=6)
Normetanephrine (nmol/L)	0.61 [0.49; 0.84]	0.59 [0.44; 0.69]	0.46
Metanephrine (nmol/L)	0.13 [0.10; 0.20]	0.16 [0.09; 0.20]	0.79
3-Methoxytyramine (nmol/L)	0.03 [0.02; 0.04]	0.03 [0.02; 0.04]	0.71

Data are median [interquartile range].

Data are on treatment with the lower dose of hydrocortisone (0.2-0.3 mg/kg/day).

RAAS interfering medication: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, betablockers.

RAAS, renin angiotensin aldosterone system.