Table 7.

Urinary glucocorticoid excretion, tryptophan-kynurenine metabolism, renin-angiotensin-aldosterone system and self-reported aspects of quality in life in patients on the higher dose hydrocortisone (0.4-0.6 mg/kg/day).

	Adrenal crisis -	Adrenal crisis +	P value
Urinary glucocorticoid excretion	(n=38)	(n=7)
24h Urinary cortisol (µmol/24h)	0.31 [0.23; 0.43]	0.18 [0.11; 0.26]	0.01
24h Urinary cortisone (µmol/24h)	0.48 [0.38; 0.71]	0.32 [0.22; 0.38]	<0.01
THS (µmol/24h)	0.05 [0.03; 0.08]	0.05 [0.02; 0.09]	0.79
THF (µmol/24h)	21.91 [15.70; 25.56]	21.60 [15.37; 27.42]	0.87
Tryptophan-kynurenine metabolism	(n=38)	(n=7)
Serum kynurenine (umol/L)	1.89 [1.52; 2.45]	2.05 [1.53; 3.18]	0.57
Serum 3-hydroxykynurenine (umol/L)	0.03 [0.02; 0.05]	0.04 [0.04; 0.07]	0.16
Serum kynurenine/tryptophan ratio	0.03 [0.02; 0.03]	0.02 [0.02; 0.03]	0.59
Renin-angiotensin-aldosterone system	(n=38)	(n=7)
Serum aldosterone (pmol/L)	91.5 [<0.4; 218.5]	249.0 [115.0; 337.0]	0.04
Plasma renin (pg/mL)	8.63 [5.89; 14.78]	22.55 [5.93; 38.72]	0.23
Potassium (mmol/L)	3.70 [3.60; 3.90]	3.90 [3.75; 4.10]	0.03
Reported symptoms	(n=38)	(n=8)
Pain, z-score	-0.41 [-0.71; 0.12]	-0.24 [-0.55; 0.58]	0.32
General fatigue, z-score	0.01 [-0.75; 0.98]	-0.66 [-1.14; 0.26]	0.17
Anxiety, z-score	-0.53 [-1.14; -0.03]	-0.02 [-0.58; 1.08]	0.18

Data are represented in Z-scores. Data are median [interquartile range].

Variables of interest were selected based on P<0.1 (+ aldosterone) on lower dose hydrocortisone treatment.

THS, tetrahydro-11-deoxycortisol; THF, tetrahydrocortisol.