TABLE 3.
Anti-proliferative activities of compounds 3a-3s against different cell lines.
| Compound no. | IC50(μM) | |||||
|---|---|---|---|---|---|---|
| KYSE70 | KYSE410 | KYSE450 | H1650 | HCC827 | SHEE | |
| 3a | 5.85 ± 0.28 | 9.70 ± 0.75 | 5.27 ± 0.31 | 33.96 ± 2.77 | >50 | >50 |
| 3b | 9.03 ± 0.82 | 17.55 ± 1.37 | 20.57 ± 1.87 | >50 | >50 | 8.05 ± 0.71 |
| 3c | 5.35 ± 0.34 | >50 | 5.47 ± 0.29 | 5.72 ± 0.33 | >50 | 22.35 ± 2.53 |
| 3d | 5.43 ± 0.21 | 6.91 ± 0.40 | 4.23 ± 0.19 | 2.99 ± 0.13 | 8.17 ± 0.42 | >50 |
| 3e | 12.60 ± 1.01 | >50 | 6.25 ± 0.35 | 21.10 ± 1.74 | >50 | >50 |
| 3f | >50 | >50 | 34.20 ± 3.01 | >50 | 17.81 ± 1.61 | 12.14 ± 1.33 |
| 3g | 5.46 ± 0.23 | >50 | 44.46 ± 4.23 | 29.58 ± 2.18 | >50 | 8.01 ± 0.83 |
| 3h | >50 | >50 | >50 | >50 | >50 | 6.03 ± 0.57 |
| 3i | 36.08 ± 3.17 | >50 | >50 | >50 | 24.23 ± 2.34 | 6.23 ± 0.62 |
| 3j | 3.72 ± 0.33 | >50 | 3.60 ± 0.27 | 4.98 ± 0.17 | 6.27 ± 0.42 | 7.2 ± 0.63 |
| 3k | 16.0 ± 1.53 | 32.00 ± 3.25 | 20.00 ± 2.25 | 16.02 ± 1.69 | 6.18 ± 0.61 | 10.33 ± 0.96 |
| 3l | 11.11 ± 0.94 | >50 | >50 | 10.02 ± 0.79 | 4.61 ± 0.28 | 4.82 ± 0.32 |
| 3m | 3.92 ± 0.15 | 5.85 ± 0.20 | 4.05 ± 0.21 | 4.27 ± 0.19 | 8.44 ± 0.37 | >50 |
| 3n | >50 | 49.70 ± 4.57 | 12.76 ± 1.25 | 35.35 ± 3.46 | 13.71 ± 1.34 | 22.59 ± 2.31 |
| 3o | >50 | 49.5 ± 5.01 | 46.76 ± 4.63 | >50 | >50 | 14.17 ± 1.61 |
| 3p | >50 | >50 | 24.90 ± 2.16 | >50 | 34.67 | >50 |
| 3q | >50 | 12.27 ± 0.93 | >50 | >50 | >50 | 28.08 ± 2.47 |
| 3r | 5.85 ± 0.52 | 8.74 ± 0.74 | 8.20 ± 0.67 | 4.32 ± 0.27 | 12.43 ± 1.07 | >50 |
| 3s | >50 | >50 | >50 | >50 | >50 | 33.26 ± 3.43 |
| Erlotinib | >50 | 5.00 ± 0.46 | 7.60 ± 0.51 | 14.00 ± 1.19 | 11.81 ± 1.02 | 20.99 ± 2.11 |
Conditions: Growth inhibition was evaluated with MTT assay. The absorbance at 490 nm was measured using a microplate reader (Thermo). The results were from statistical analysis and were presented as mean ± SD.