TABLE 1.
Clinical characteristics of the COAD patients.
| Characteristic | Levels | Overall |
|---|---|---|
| N | 478 | |
| Tumor extent (T) stage, n (%) | T1 | 11 (2.3%) |
| T2 | 83 (17.4%) | |
| T3 | 323 (67.7%) | |
| T4 | 60 (12.6%) | |
| Lymph node invasion (N) stage, n (%) | N0 | 284 (59.4%) |
| N1 | 108 (22.6%) | |
| N2 | 86 (18%) | |
| Detectable metastasis (M) stage, n (%) | M0 | 349 (84.1%) |
| M1 | 66 (15.9%) | |
| Pathologic stage, n (%) | Stage I | 81 (17.3%) |
| Stage II | 187 (40%) | |
| Stage III | 133 (28.5%) | |
| Stage IV | 66 (14.1%) | |
| Age, n (%) | <=65 | 194 (40.6%) |
| >65 | 284 (59.4%) | |
| Lymphatic invasion, n (%) | NO | 266 (61.3%) |
| YES | 168 (38.7%) | |
| Overall survival (OS) event, n (%) | Alive | 375 (78.5%) |
| Dead | 103 (21.5%) | |
| Gender, n (%) | Female | 226 (47.3%) |
| Male | 252 (52.7%) | |
| Age, median (IQR) | 69 (58, 77) |
Note: A small amount of samples may be lost during the statistics of different clinical variables in the TCGA database. T1, the carcinoma invaded the submucosa but not involve the lamina propria; T2, the carcinoma invaded the lamina propria; T3, the carcinoma penetrated the lamina propria; T4, the carcinoma invaded the visceral peritoneum or adhered to adjacent organs; N0, no regional lymph node metastasis; N1, limited to 1–3 regional lymph node metastases, or no regional lymph node metastasis, but any number of tumor nodules; N2, four or more regional lymph nodes metastases; M0, imaging showed no distant metastasis; M1, metastases to one or more distant sites, organs, or peritoneum; Stage I, the carcinoma confined within the intestinal wall; Stage II, the carcinoma penetrated the intestinal wall and invaded the mucosa or serosa without lymph node metastasis; Stage III, local lymph node metastasis; and Stage IV, invasion of adjacent organs or distant metastasis.