TABLE 2.

Correlation analysis between SLC7A11 and immune cell markers in TIMER and GEPIA.

Cell Type	Gene Symbol	None		Purity		Tumor		Normal
		Core	P	Core	P	R	P	R	P
Tumor associated	MS4A4A	0.08	0.087	−0.379	**	0.06	0.32	0.15	0.34
Macrophage (TAM)	CCL2	0.127	**	−0.354	**	0.003	0.96	0.14	0.38
	CCR5	0.091	0.052	−0.436	**	0.11	0.058	0.38	0.14
	CD80	0.103	*	−0.313	**	0.028	0.64	0.41	**
	CD86	0.131	**	−0.42	**	0.081	0.15	0.2	0.22
Monocyte	CD14	0.003	0.954	−0.394	**	0.07	0.25	0.13	0.43
	CD16	−0.027	0.567	−0.222	**	0.11	0.065	0.2	0.22
	CD115	−0.034	0.468	−0.366	**	0.022	0.72	0.18	0.25
Neutrophil	CD11b	−0.098	*	−0.25	**	0.013	0.83	0.25	0.11
	CD15	0.219	**	0.019	0.699	*	0.86	0.37	*
	CD66b	−0.259	**	0.103	*	−0.045	0.46	0.27	0.09
NK	CD7	0.013	0.783	−0.472	**	0.11	0.061	-0.084	0.6
	XCL1	−0.021	0.66	−0.241	**	0.019	0.76	-0.14	0.39
	KIR3DL1	0.113	*	−0.249	**	0.36	**	0.099	0.54
Dendritic cell	CD1C	−0.073	0.121	−0.331	**	−0.076	0.21	0.085	0.6
	CD11c	0.061	0.196	−0.427	**	0.06	0.32	0.45	**
	CD141	0.038	0.42	−0.361	**	0.018	0.77	0.2	0.21
B cell	CD19	−0.132	**	−0.414	**	−0.0096	0.87	0.23	0.14
	CD20	0.005	0.917	−0.023	0.64	−0.014	0.82	0.31	*
	CD38	−0.023	0.621	−0.384	**	0.05	0.4	0.19	0.23
CD8+ T cell	CD8A	0.114	*	−0.397	**	0.22	**	0.043	0.79
	CD8B	0.01	0.832	0.221	**	0.05	0.41	-0.1	0.52
Th1	TBX21	0.123	**	−0.4	**	0.17	**	0.13	0.4
	STAT4	0.147	**	−0.377	**	0.12	0.053	0.095	0.55
	IL12RB2	0.113	*	−0.238	**	0.17	**	0.1	0.52
	IL27RA	0.039	0.408	−0.24	**	0.13	*	0.22	0.16
	STAT1	0.259	**	−0.274	**	0.29	**	0.096	0.55
	IFN-γ	0.176	**	−0.241	**	0.27	**	0.1	0.53
	TNF-α	−0.02	0.67	−0.255	**	0.022	0.72	-0.026	0.87
Th2	GATA3	−0.065	0.16	−0.364	**	-0.028	0.64	0.22	0.17
	CCR3	−0.068	0.15	−0.173	**	0.006	0.92	-0.25	0.12
	STAT6	−0.005	0.91	0.012	0.815	0.012	0.85	-0.03	0.85
	STAT5A	−0.096	*	−0.161	**	0.039	0.52	0.078	0.63
Th17	STAT3	0.187	**	−0.225	**	0.067	0.27	0.28	0.073
	IL-17 A	−0.064	0.175	−0.012	0.814	−0.038	0.53	0.27	0.092
	IL-21R	−0.023	0.626	−0.441	**	0.058	0.34	0.32	*
	IL-23R	0.024	0.61	0.023	0.65	−0.041	0.5	0.098	0.54
Treg	FOXP3	−0.095	*	−0.382	**	−0.038	0.53	0.26	0.1
	IL2RA	0.098	*	−0.401	**	0.11	0.075	0.4	**
	CCR8	0.014	0.76	−0.336	**	−0.029	0.63	0.33	*
Macrophage	CD68	0.031	0.51	−0.317	**	0.047	0.44	0.24	0.14
	CD11b	−0.006	0.89	−0.355	**	0.013	0.83	0.25	0.11

Note: None, Correlation without adjustment. Purity, correlation adjusted by purity. Cor, R value of Spearman’s correlation. *p < 0.05; **p < 0.01.