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. 2022 Apr 20;13:836635. doi: 10.3389/fphar.2022.836635

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Copyright © 2022 Hoshino, Soma, Uchida, Shiko, Nakagome and Nagata.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of sputum granulocyte-predominant subtypes in the type 2 biomarker-classified subgroups. Of successful sputum induction, 75 adequate sputum samples were examined. Patients were divided into four subtypes according to the cutoff values of sputum eosinophilia (≥2.7%) and predominant neutrophil (≥50.0%). Values were analyzed using Fisher’s exact test. In the FeNO^lo/B-EOS^lo subgroup, the eosinophil-predominant, mixed-granulocyte, neutrophil-predominant, and paucigranulocyte subtypes were as follows: 5.9, 0.0, 52.9, and 41.2%, respectively. In the FeNO^hi/B-EOS^lo subgroup: 46.7, 13.3, 26.7, and 13.3%, respectively. In the FeNO^lo/B-EOS^hi subgroup: 33.3, 14.3, 14.3, and 38.1%, respectively. In the FeNO^hi/B-EOS^hi subgroup: 68.2, 4.5, 18.2, and 9.1%, respectively. FeNO^lo, low FeNO; FeNO^hi, high FeNO; B-EOS^lo, low B-EOS; B-EOS^hi, high B-EOS. *, significantly high or low, compared with the other FeNO/B-EOS subgroups.