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. 2022 Apr 20;13:836635. doi: 10.3389/fphar.2022.836635

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Copyright © 2022 Hoshino, Soma, Uchida, Shiko, Nakagome and Nagata.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the future risk of asthma exacerbations after the entry between the groups of biologics use annual subsequent (A) all asthma exacerbations and (B) severe asthma exacerbations was examined using the Kruskal–Wallis test and Bonferroni correction for post hoc pairwise analyses. (C) All asthma exacerbations-free time from the entry are examined using Kaplan–Meier analysis. (A)*vs. no biologics, p = 0.001; **vs. mepolizumab and benralizumab, p = 0.01. (B)†vs. no biologics, p = 0.0007; ††vs. mepolizumab and benralizumab, p = 0.01.