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. 2022 Apr 20;13:850066. doi: 10.3389/fphar.2022.850066

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Copyright © 2022 Abdel-latif, Heeba, Hassanin, Waz and Amin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of NaHS and PAG on rats’ liver tissues stained with hematoxylin and eosin (H&E) in CP- induced hepatotoxicity (×200 and ×400). Liver tissue of control group (A) showed normal morphological features of hepatic parenchyma with many apparent intact radiating hepatocytes. Liver tissues of rats treated with CP (B) showed sever diffuse hepatocellular vacuolar degeneration with karyopyknosis (arrow) accompanied with moderate dilatation of hepatic blood vessels (star) and mild records of periportal inflammatory cells infiltrates (red arrow). Liver tissues of NaHS rat group) showing intact histological structure of hepatic lobule with few degenerative changes (black arrow) mild hepatic blood vessel dilatation (star) or inflammatory cells infiltrates (C). microscopic examination of liver tissues of PAG rat group (D) showed wide diffuse areas of vacuolar degenerative changes of most of hepatocytes (arrow) with many dilated, congested hepatic blood vessels (star) and mild records of focal perivascular inflammatory cells infiltrates (red arrow).