Classification of histone deacetylases (HDACs) enzymesa.
| Class | Member | PDB code | Location | Expression |
|---|---|---|---|---|
| Class I (Zn2+-dependent) | HDAC1 | 4BKX 13 | Nucleus | Ubiquitous |
| HDAC2 | 4LXZ 14 | |||
| HDAC3 | 4A69 15 | |||
| HDAC8 | 1T64 16 | |||
| Class IIa (Zn2+-dependent) | HDAC4 | 2VQM 17 | Nucleus/cytoplasm | Specific |
| HDAC5 | — | |||
| HDAC7 | 3C10 18 | |||
| HDAC9 | — | |||
| Class IIb (Zn2+-dependent) | HDAC6 | 5EDU 19 | Mainly cytoplasm | Specific |
| HDAC10 | — | |||
| Class III (NAD+-dependent) | SIRT1 | 4ZZH 20 | Nucleus | Ubiquitous |
| SIRT2 | 1J8F 21 | Cytoplasm | ||
| SIRT3 | 3GLS 22 | Mitochondria | ||
| SIRT4 | — | Mitochondria | ||
| SIRT5 | 3RIG 23 | Mitochondria | ||
| SIRT6 | 3K35 24 | Nucleus | ||
| SIRT7 | 5IQZ 25 | Nucleus | ||
| Class IV (Zn2+-dependent) | HDAC11 | — | Nucleus/cytoplasm | Ubiquitous |
a
“–” This type Homo sapiens HDAC isoform don't display PDB code.