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. 2022 Apr 20;13:862125. doi: 10.3389/fphar.2022.862125

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Copyright © 2022 Ghallab, Eissa and El Tayebi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AZD5069 prevents doxorubicin-mediated TGF-β upregulation in 3D culture. TGF-β concentration levels were obtained from ELISA and were compared in different treatment conditions. Data are expressed as TGF-β concentration. Dox: doxorubicin; AZD: AZD5069. p values: The TGF-β concentration level of each combined treatment group was compared to the concentration of the corresponding AZD dose alone using unpaired Student’s t-test.