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. 2022 Apr 20;13:862125. doi: 10.3389/fphar.2022.862125

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Copyright © 2022 Ghallab, Eissa and El Tayebi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXCR2 inhibition by AZD5069 diminishes doxorubicin chemoresistance in MDA-MB-231 mammospheres. (A) Cell cytotoxicity in control and treated conditions obtained from the LDH assay. Data are expressed as cytotoxicity percentage. Dox: doxorubicin; AZD: AZD5069. p values: The cytotoxicity of each combined treatment group was compared to the cytotoxicity of doxorubicin alone using unpaired Student’s t-test. ****p < 0.0001, ns = p = 0.2473. (B) Cell cytotoxicity in control and treated conditions obtained from the LDH assay. Data are expressed as cytotoxicity percentage. Dox: doxorubicin; AZD: AZD5069. p values. The cytotoxicity of each combined treatment group was compared to the cytotoxicity of the corresponding dose of AZD alone using unpaired Student’s t-test. ****p < 0.0001, **p ≤ 0.002.