TABLE 1.

Intervene fatty acid β-oxidation in AKI.

Model	Treatment	Regulatory factor	Effect on kidney injury	Reference
Cisplatin	Genetic or pharmacological inhibition of cyclophilin D	PPARα activity↑Fatty acid oxidation↑Lipid accumulation↓	Mitochondrial function↑ Apoptotic↓ Inflammation↓ Cell cycle G2/M arrest↓	Jang et al. (2020)
Cisplatin	SIRT3 agonist	LKB1-AMPK pathway↑ Fatty acid oxidation↑ Lipid accumulation↓	Mitochondrial function↑ Renal function↑ Necrosis↓	Li et al. (2020b)
Cisplatin/Ischemic AKI	SIRT5-deficient mice	Peroxisomal fatty acid oxidation↑	Tubular injury↓ Oxidative stress↓ Renal function↑	Chiba et al. (2019)
Cisplatin	UCP1 agonist	AMPK/ULK1 pathway↑Lipid accumulation↓	Apoptotic↓ Inflammation↓ Autophagy↑	Xiong et al. (2021)
Cisplatin	PPARα ligand	PPARα activity↑ Fatty acid oxidation↑ Pyruvate dehydrogenase kinase-4 (PDK4)↑	Apoptotic↓ Inflammation↓ Necrosis	Li et al. (2004)