Laccase-catalyzed iodination of 4-hydroxyarylketones and related compounds 1h–p^a.

Entry	1	Laccase (U)	Time (h)	Yield products (%)
1	h	45 + 90	15
2	i	45 + 90	15
3	j	45 + 180	168
4	k	45 + 180	15
5	l	45 + 225	24
6d	m	45 + 360	168
7	n	45 + 180	60
8e	o	45 + 360	120
9	p	45 + 90	24

^a2 mmol 1 were reacted in 90 mL buffer. The yields of 2 and 4 refer to isolated yields. Initially, 45 U enzyme were added, additionally laccase in buffer was added during 5 h by syringe pump. Substrate in 3 mL DMSO was added by a second syringe pump during the same time the enzyme was added. Substrates with one iodination site were reacted with 3 equiv. KI, substrates with 2 iodination sites were reacted with 4 equiv. KI.

^bInitially, 1.1 equiv. KI and the substrate were added as solids. No DMSO was used. 180 U enzyme were added during 12 h.

^c180 mL buffer and 6 equiv. KI were used. 300 U additional enzyme and substrate were added during 5 h.

^dAdditional enzyme and substrate were added during 30 h.

^eAdditional enzyme and substrate were added during 20 h.