Laccase-catalyzed iodination of 4-hydroxybenzoic acid derivatives and related compounds 1q–t^a.

Entry	1	Laccase (U)	Time(h)	Yield products (%)
1	q	45 + 90	36
2b	r	45 + 180	120
3c	s	45 + 500	48
4	t	45 + 270	24

^a2 mmol 1 were reacted in 90 mL buffer. The yields of 2 and 4 refer to isolated yields. Initially, 45 U enzyme were added, additionally laccase in buffer was added during 5 h by syringe pump. Substrate in 3 mL DMSO was added by a second syringe pump during the same time the enzyme was added. Substrates with one iodination site were reacted with 3 equiv. KI, substrates with 2 iodination sites were reacted with 4 equiv. KI.

^bAdditional enzyme and substrate were added during 10 h.

^cAdditional enzyme and substrate were added during 30 h.