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. 2022 Apr 20;12:780186. doi: 10.3389/fonc.2022.780186

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Copyright © 2022 Jiang, Zhang, Chen, Chen, Guo, Ma, Gao, Mei, Zhang and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glycolysis pathways of ¹⁸F-FDG and normal glucose and related metabolic pathways regulated by epidermal growth factor receptor (EGFR) signaling in EGFR-mutated non-small cell lung cancer (NSCLC). ¹⁸F-FDG is transported into cells by glucose transporters (GLUTs) and phosphorylated to ¹⁸F-FDG-6-phosphate by hexokinase (HK). It is trapped inside cells because ¹⁸F-FDG-6-phosphate is not a substrate of glycolysis or pentose phosphate pathway (PPP) and is unable to diffuse outside cells. The metabolites of pyruvate and ribose-5-phosphate in the glycolysis decreased significantly after treatment of lung adenocarcinoma cells with EGFR tyrosine kinase inhibitors (TKIs) (33).