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. 2022 Apr 20;13:860311. doi: 10.3389/fimmu.2022.860311

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Copyright © 2022 Han, Bian, Yang, Wang, Li, Yang, Ansari, Gershwin, Zeng, Lian and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diversity of TCR repertoire of hepatic CD8αα and CD8αβ T cells of TG mice. (A) Percentage of the top 5 TCR β-chain clonotypes in CD8αβ and CD8αα T cells from TG mice. (B) Frequency of functional V chains in CD8αβ and CD8αα T cells from TG mice. (C, D) Heat-maps of TCR β-chain V-J pairing usages in count (left) and type (right) for CD8αβ (left) and CD8αα (right) cells from TG mice. (E) CDR3 repertoire amino acid (AA) length distribution of TCRβ chain in CD8αβ and CD8αα cells from TG mice. (F–H) Diversity index of TCR β-chain repertoires in CD8αβ and CD8αα cells from TG mice, including Shannon’s index (F), Margalef’s index (G) and Simpson’s Reciprocal index (H).