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Schematic of antigen-specific immunogenicity by MN delivery system. MN arrays can deliver antigen/or therapeutic agents into the dermal layers. In the next steps, antigens are processed by local APCs, leading to activation of T lymphocytes (CD8, CD4+ lymphocytes) and B cells. In addition to the production of numerous cytokines, immune cells like NK cells and CD8 lymphocytes can directly invade the tumor cells.
