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. 2022 Apr 20;12:836257. doi: 10.3389/fonc.2022.836257

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Copyright © 2022 Deng, Hu, Miao, Wang, Zhang, Wan, Wu, Lv, Feng, Ji, Park and Hao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A, B) Mice bearing IOMM meningiomas were treated with intraperitoneal injections of FK866 or DMSO on day 10, and the tumors were collected on day 25 (N=5/group).(C) The tumor volume at 3, 6, 9, 12 and 15 days after treatment. Tumor size (mm3) = [d2 x D]/2, d is the shortest diameter and D is the largest diameter. (D) The results of tumor weight analysis. (E, F) Immunohistochemical staining for Ki-67, PD-L1, B7-H3 in IOMM cell-derived meningiomas treated with DMSO and FK866. *p < 0.05, **p < 0.01, ****p < 0.0001.