TABLE 3.
List of identified genetic alteration at chromosome level and tissue marker present in OPMDs.
| OPMD Type | Chromosome Altered | Tissue Marker |
|---|---|---|
| Leukoplakia | Deletion - 3p14, 4q, 8p, 9p21, 11q, 17p | p53, PD-L1 |
| Allelic imbalance- 3p21, 8p21-23, 9p21, 13q14.2, 17p13.1, 18q21.1 | ||
| CNV- 3p, 8p, 9p, 11q, 13q, 18q, 7p | ||
| Oral lichen planus | Genetic alteration - 3p, 9p, 17p | CD4+, CD8+ T cell, TLR-2, p53, TNF-α, IL-6, COX-2, and CD34 |
| Monosomy of chromosome 9 | ||
| Oral submucous fibrosis | LOH- 1, 3, 4, 6, 7, 9, 10, 11, 12, 13, 15, 18, 19, 20 | TGF-β |
| Erythroplakia | Polysomy of chromosomes 7 and 17 | p53 |
| LOH or allelic gain at 9p, and 3p | ||
| Proliferative verrucous leukoplakia | Allelic loss at 9p21 (INFα, D9S1748, and D9S171) | p53, Mcm2 |
| Oral cancer | CNV- 3, 5, 7, 8, 9, 11 | p53 |