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. 2001 Aug;45(8):2363–2367. doi: 10.1128/AAC.45.8.2363-2367.2001

TABLE 1.

Comparative in vitro activities of ABT-773 against aerobic and anaerobic bacteria isolated from patients with sinusitis

Organism (no.)b and agent MIC (μg/ml)
Range 50% 90%
Haemophilus spp.c (33)
 ABT-773 1–>4 4 4
 Erythromycin 2–>8 4 8
 Azithromycin 1–4 2 4
 Clarithromycin 4–>8 >8 >8
 Amoxicillin ≤0.06–>8 0.5 >8
 Cefuroxime ≤0.06–1 0.5 1
 Levofloxacin ≤0.03 ≤0.03 ≤0.03
Moraxella catarrhalis (11)
 ABT-773 0.06–0.125 0.125 0.125
 Erythromycin 0.125–0.25 0.25 0.25
 Azithromycin ≤0.06 ≤0.06 ≤0.06
 Clarithromycin 0.125–0.25 0.125 0.125
 Amoxicillin ≤0.06–2 1 2
 Cefuroxime 0.25–2 1 2
 Levofloxacin ≤0.03–0.06 ≤0.03 0.06
Staphylococcus aureus (39)
 ABT-773 ≤0.03–0.06 ≤0.03 0.06
 Erythromycin 0.125–>8 0.125 >8
 Azithromycin 0.5–>8 1 >8
 Clarithromycin 0.125–>8 0.25 >8
 Amoxicillin ≤0.06–>8 8 >8
 Cefuroxime 0.25–8 1 2
 Levofloxacin 0.06–>4 0.125 0.25
Staphylococcus spp., coagulase  negatived (32)
 ABT-773 ≤0.03–>4 0.06 >4
 Erythromycin ≤0.06–>8 >8 >8
 Azithromycin 0.25–>8 >8 >8
 Clarithromycin ≤0.06–>8 >8 >8
 Amoxicillin ≤0.06–>8 1 8
 Cefuroxime 0.125–4 0.5 4
 Levofloxacin 0.124–>4 0.25 2
Streptococcus pneumoniae (27)
 ABT-773 ≤0.03–1 ≤0.03 ≤0.03
 Erythromycin ≤0.06–8 ≤0.06 ≤0.06
 Azithromycin ≤0.06–>8 0.125 0.5
 Clarithromycin ≤0.06–8 ≤0.06 ≤0.06
 Amoxicillin ≤0.06–1 ≤0.06 0.5
 Cefuroxime ≤0.06–8 ≤0.06 1
 Levofloxacin 0.125–1 0.5 1
Streptococcus spp.e (22)
 ABT-773 ≤0.03–0.06 ≤0.03 ≤0.03
 Erythromycin ≤0.06–>8 ≤0.06 4
 Azithromycin ≤0.06–>8 ≤0.06 >8
 Clarithromycin ≤0.06–>8 ≤0.06 4
 Amoxicillin ≤0.06–2 ≤0.06 1
 Cefuroxime ≤0.06–>8 ≤0.06 1
 Levofloxacin ≤0.03–>4 1 2
Corynebacterium spp.f (6)
 ABT-773 ≤0.03 0.06 —n
 Erythromycin 0.25–>8 4 — 
 Azithromycin 2–>8 >8 — 
 Clarithromycin 0.25–>8 1 — 
 Amoxicillin ≤0.06–0.5 0.125 —
 Cefuroxime ≤0.06–0.25 0.125 —
 Levofloxacin 0.06–>4 0.125 —
Eikenella corrodens (10)
 ABT-773 0.125–2 1 1
 Erythromycin 4–>8 8 >8
 Azithromycin 1–>8 4 >8
 Clarithromycin 4–>8 8 >8
 Amoxicillin 0.5–1 0.5 1
 Cefuroxime 1–>8 4 >8
 Levofloxacin ≤0.03 ≤0.03 ≤0.03
Enterobacteriaceaeg (21)
 ABT-773 4–>4 >4 >4
 Erythromycin >8 >8 >8
 Azithromycin 4–>8 >8 >8
 Clarithromycin >8 >8 >8
 Amoxicillin 2–>8 >8 >8
 Cefuroxime 0.25–>8 8 >8
 Levofloxacin ≤0.03–0.125 ≤0.03 0.125
Miscellaneous gram-negative  bacteriah (6)
 ABT-773 1–>4 >4 — 
 Erythromycin 4–>8 >8 — 
 Azithromycin 0.5–>8 >8 — 
 Clarithromycin 4–>8 >8 — 
 Amoxicillin >8 >8 — 
 Cefuroxime 0.25–>8 >8 — 
 Levofloxacin 0.06–>4 0.5 — 
Fusobacterium spp.i (20)
 ABT-773 ≤0.08–8 2 8
 Erythromycin
  pH 7 0.5–>32 8 32
  pH 8 ≤0.03–16 8 32
 Azithromycin
  pH 7 ≤0.03–1 0.5 1
  pH 8 ≤0.03–2 0.5 1
 Clarithromycin
  pH 7 8–32 8 16
  pH 8 ≤0.03–16 0.25 8
 Amoxicillin ≤0.03–2 ≤0.03 0.25
 Cefuroxime ≤0.03–1 ≤0.03 0.5
 Levofloxacin ≤0.03–2 1 1
Prevotella spp.j (10)
 ABT-773 ≤0.08–0.125 0.06 0.125
 Erythromycin
  pH 7 0.06–8 0.5 1
  pH 8 ≤0.03–0.5 0.125 0.25
 Azithromycin
  pH 7 0.06–16 0.125 0.25
  pH 8 0.06–2 0.125 0.25
 Clarithromycin
  pH 7 ≤0.03–4 0.06 0.25
  pH 8 ≤0.03–0.5 ≤.03 0.125
 Amoxicillin ≤0.03–>32 2 >32
 Cefuroxime 0.06–>32 8 >32
 Levofloxacin 0.5–4 1 1
Prevotella melaninogenica (13)
 ABT-773 0.015–0.125 0.03 0.125
 Erythromycin
  pH 7 0.125–32 0.5 4
  pH 8 ≤0.03–2 0.125 0.25
 Azithromycin
  pH 7 0.06–>32 0.125 8
  pH 8 0.06–1 0.125 0.5
 Clarithromycin
  pH 7 ≤0.03–4 0.06 2
  pH 8 ≤0.03–0.25 ≤0.03 0.06
 Amoxicillin 0.125–>32 8 >32
 Cefuroxime 0.25–>32 32 >32
 Levofloxacin 0.5–>8 1 1
Propionibacterium spp.k (28)
 ABT-773 ≤0.08–0.015 ≤0.08 0.015
 Erythromycin
  pH 7 ≤0.03–0.06 0.06 0.06
  pH 8 ≤0.03 ≤0.03 ≤0.03
 Azithromycin
  pH 7 ≤0.03–0.125 0.06 0.125
  pH 8 ≤0.03–0.06 ≤0.03 ≤0.03
 Clarithromycin
  pH 7 ≤0.03–0.06 ≤0.03 0.06
  pH 8 ≤0.03 ≤0.03 ≤0.03
 Amoxicillin ≤0.03–0.5 0.125 0.25
 Cefuroxime 0.06–1 0.125 1
 Levofloxacin 0.125–0.5 0.25 0.5
Peptostreptococcus magnus (40)
 ABT-773 ≤0.08–0.5 0.03 0.03
 Erythromycin
  pH 7 2–>32 4 4
  pH 8 0.5–>32 1 2
 Azithromycin
  pH 7 1–>32 2 4
  pH 8 0.5–>32 0.5 2
 Clarithromycin
  pH 7 1–>32 2 2
  pH 8 0.5–>32 1 1
 Amoxicillin 0.06–0.25 0.25 0.25
 Cefuroxime 0.5–32 4 16
 Levofloxacin 0.125–>8 0.25 0.5
Peptostreptococcus micros (16)
 ABT-773 ≤0.08–>8 0.03 0.03
 Erythromycin
  pH 7 0.25–>32 1 2
  pH 8 0.125–>32 0.25 0.5
 Azithromycin
  pH 7 0.5–>32 1 1
  pH 8 0.125–>32 0.25 0.25
 Clarithromycin
  pH 7 0.25–>32 0.5 1
  pH 8 0.125–>32 0.125 0.25
 Amoxicillin ≤0.03–4 0.25 4
 Cefuroxime 0.125–4 1 4
 Levofloxacin 0.06–1 0.5 0.5
Peptostreptococcus spp.l (12)
 ABT-773 ≤0.08–0.5 0.015 0.03
 Erythromycin
  pH 7 ≤0.03–>32 2 4
  pH 8 ≤0.03–>32 0.5 1
 Azithromycin
  pH 7 0.125–>32 2 2
  pH 8 ≤0.03–>32 0.5 2
 Clarithromycin
  pH 7 ≤0.03–>32 0.5 1
  pH 8 0.5–8 0.25 1
 Amoxicillin ≤0.03–1 0.125 0.25
 Cefuroxime 0.06–16 4 16
 Levofloxacin 0.25–8 4 4
Veillonella spp. (13)
 ABT-773 ≤0.008–4 1 2
 Erythromycin
  pH 7 2–32 8 32
  pH 8 0.25–8 2 8
 Azithromycin
  pH 7 1–16 2 16
  pH 8 0.25–2 0.5 2
 Clarithromycin
  pH 7 1–32 4 32
  pH 8 0.5–8 2 8
 Amoxicillin 0.25–8 2 4
 Cefuroxime 2–16 8 16
 Levofloxacin 0.25–8 0.25 0.5
Other anaerobesm (10)
 ABT-773 ≤0.08–>8 1 2
 Erythromycin
  pH 7 0.125–>32 2 16
  pH 8 ≤0.03–>32 1 16
 Azithromycin
  pH 7 ≤0.03–>32 4 16
  pH 8 ≤0.03–>32 1 16
 Clarithromycin
  pH 7 0.06–>32 1 8
  pH 8 ≤0.03–>32 0.5 8
 Amoxicillin ≤0.03–>32 1 32
 Cefuroxime ≤0.03–>32 8 >32
 Levofloxacin ≤0.03–>8 1 8
a

no., number of isolates tested. 

b

MIC50, MIC at which 50% of the isolates tested were inhibited. 

c

Includes 25 H. influenzae, 6 H. parainfluenzae, and 2 H. paraphrophilus isolates. 

d

Includes 24 Staphylococcus epidermidis, 1 S. hyicus, 1 S. lugdenensis, 1 S. saprophyticus, 1 S. warnerii, 1 S. auricularis, 1 S. capitis, and 2 other coagulase-negative species isolates. 

e

Includes 1 Streptococcus agalactiae, 3 S. anginosus, 1 group G beta-hemolytic streptococcus, and 2 other alpha-hemolytic streptococcal isolates and 1 S. constellatus, 2 S. mitis, 7 S. sanguis I and II, 1 S. salivarius, 1 S. pyogenes, 2 Gemella morbillorum, and 1 Enterococcus faecalis isolates. 

f

Includes 2 Corynebacterium amycolatum, 1 C. minutissimum, 1 C. pseudodiphtheriticum, and 2 other Corynebacterium species isolates. 

g

Includes 6 E. coli, 2 Citrobacter koseri, 2 Enterobacter aerogenes, 3 Enterobacter cloacae, 1 Hafnia alvei, 2 Klebsiella oxytoca, 1 Klebsiella pneumoniae, 1 Pantoea agglomerans, 1 Serratia liquefaciens, and 2 Serratia marcescens isolates. 

h

Includes 3 Pseudomonas aeruginosa, 1 Acinetobacter baumannii, 1 Acinetobacter lwoffi, and 1 Bordetella bronchiseptica isolates. 

i

Includes 16 F. nucleatum, 1 F. necrophorum, 2 F. naviforme, and 1 F. varium isolates. 

j

Includes 1 P. bivia, 6 P. buccae, 1 P. intermedia, and 2 P. oris isolates. 

k

Includes 12 P. acnes, 8 P. avidum, and 8 P. granulosum isolates. 

l

Includes 1 P. anaerobius, 5 P. asaccharolyticus, 2 P. prevotii, and 4 other Peptostreptococcus sp. isolates. 

m

Includes 1 Actinomyces sp., 1 Bilophila wadsworthia, 1 Eubacterium lentum, 1 Bacteroides capillosus, 2 Bacteroides fragilis, 1 Bacteroides uniformis, 2 Campylobacter gracilis, and 1 Clostridium paraputrificum isolates. 

n

—, not calculated.