Results of regression analysis for responses Y₁ (particle size, nm), Y₂ (transmittance, %) and Y₃ (PDI).

Quadratic model	R 2	Adjusted R2	Predicted R2	Standard deviation (SD)	% coefficient of variation (CV)
Response (Y1)	0.9958	0.9940	0.9918	2.60	2.07
Response (Y2)	0.9914	0.9855	0.9820	0.5715	0.6438
Response (Y3)	0.9924	0.9872	0.9840	0.0097	2.55
Y 1 = +124.99 + 3.16 × X1 + 2.51 × X2 + 2.18 × X3 + 1.18 × X4 + 1.69 × X5 − 16.78 × X1X2 + 35.70 × X1X3 + 5.43 × X1X4 + 1.94 × X1X5 − 0.2282 × X2X3 + 4.24 × X2X3 + 1.94 × X2X5 − 9.06 × X3X4 + 0.7784 × X3X5 + 1.94 × X4X5					(1)
Y 2 = +82.11 − 0.5480 × X1 − 0.2094 × X2 − 0.6640 × X3 − 0.7191 × X4 + 1.18 × X5 + 43.16 × X1X2 − 0.7509 × X1X3 + 1.98 × X1X4 − 0.6095 × X1X5 + 1.26 × X2X5 − 0.3856 × X2X4 − 1.45 × X2X5 − 0.9753 × X3X5 + 1.26 × X3X5–1.43 × X4X5 + 1.61 × X12 + 1.86 × X22 + 1.79 × X32 + 1.78 × X42 + 0.4287 × X52					(2)
Y 3 = +0.3333 + 0.0072 × X1 + 0.0377 × X2 − 0.0295 × X3 + 0.0173 × X4 − 0.0057 × X5 + 0.0008 × X1X2 − 0.0110 × X1X3 + 0.0104 × X1X4 − 0.0052 × X1X5 − 0.0054 × X2X3 + 1.26 × X2X5 + 0.0263 × X2X4 − 0.0195 × X2X5 − 0.0110 × X3X5 + 0.291 × X4X5 + 0.0351 × X12 − 0.0107 × X22 + 0.0091 × X32 − 0.0072 × X42 + 0.0322 × X52					(3)