Synthesis of spirooxindole-2-azapyrrolizidine derivatives.

Entrya	Isatin 1a–g		Product 4a–h	Time (h)	Yieldb (%)	mp (°C)
	R 1	R 2
1	H	H	4a	3	95	260
2	Me	H	4b	4	85	280
3	H	Cl	4c	4	80	300
4	H	F	4d	5	79	304
5	H	Br	4e	5	90	318
6	H	I	4f	5	85	291
7	H	NO2	4g	6	78	340
8	H	OMe	4h	5	90	271

^aReactions conditions: isatin derivatives (1 mmol), malononitrile (1 mmol), and hydantoin (1 mmol).

^bIsolated yield.