Synthesis of 2-azapyrrolizidine derivatives.

Entrya	Aldehyde				Product	Time (h)	Yieldb (%)	mp (°C)
	R 1	R 2	R 3	R 4
1	H	H	OMe	H	4i	3	95	260
2	H	H	Me	H	4j	3	95	260
3	H	H	H	H	4k	1	92	275
4	OMe	H	OMe	H	4l	6	50	245
5	H	H	Br	H	4m		74	271
6	H	NO2	H	H	4n	6	85	265
7	H		Cl	H	4o	2	96	281
8	Cl		H	Cl	4p	5	54	265

^aReactions conditions: aldehyde derivatives (1 mmol), malononitrile (1 mmol), and hydantoin (1 mmol).

^bIsolated yield.