Table 1.
CD4+CD25highCD127low regulatory T cells (Treg) RNA-Seq experiments led to identification of numerous differentially expressed genes (DEGs) in Treg in four groups of mice (n = 2).
| Comparison of groups | Genes annotated | Genes with P.Value <0.05 | Genes with |log2FC| >1 | |
|---|---|---|---|---|
| SM vs NS | 19121 | 1105 | 648 | ↑ 211 |
| ↓ 437 | ||||
| M vs NS | 1171 | 902 | ↑ 233 | |
| ↓ 669 | ||||
| SM+M vs NS | 2539 | 1630 | ↑ 630 | |
| ↓ 1000 | ||||
| SM+M vs M | 2196 | 1507 | ↑ 743 | |
| ↓ 764 | ||||
| SM+M vs SM | 912 | 710 | ↑ 349 | |
| ↓ 361 | ||||
To determine the various stimulation effects on Treg transcriptome, the comparisons were made in five pairs: i) SM versus NS; ii) M versus NS; iii) SM_M versus NS; iv) SM_M versus M; and v) SM_M versus SM.
↑means up-regulated; ↓means down-regulated.